原著論文へのリンク
Citationへのリンク
Impact Factrへのリンク
顕著な業績へのリンク
新聞掲載された研究成果へのリンク
総説ベスト3
2017
原著論文
Harada Y, Takayama F, Tanabe K, Ni J, Hayashu Y, Yamamoto K, Wu Z, Nakanishi
H. Overexpression of cathepsin E interferes with neuronal differentiation
of P19 embryonal teratocarcinoma cells by degradation of N-cadherin. Cell Mol Neurobiol 37, 437-443, 2017.
Ni J, Wu Z, Meng J, Zhu A, Zhong X, Wu S, Nakanishi H. The neuroprotective effects of Brazilian green propolis on neurodegenerative damage in human neuronal SH-SY5Y cells. Oxid Med Cell Longev 2017: 7984327, 2017.
Zhang X, Wu Z, Liu Y, Ni J, Deng C, Zhao B, Nakanishi H, He J,
Yan X. Boi-ogi-to (TJ-20), a Kampo formula, suppresses the inflammatory
bone destruction and expression of cytokines in the synovia of ankle joints
of adjuvant arthritic rats. Evid Based Complement Altemat Med 2017:3679295, 2017.
Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P, Nakanishi
H. Cathepsin B plays a critical role in inducing Alzheimer’s disease-like
phenotypes following chronic systemic exposure to lipopolysaccharide from
Porphyromonas gingivalis in mice. Behav Brain Immun 65: 350-361 2017.
Dekita M, Wu Z, Ni J, Zhang X, Liu Y, Yan X, Nakanishi H, Takahasi I. Cathepsin
S is involved in Th17 differentiation through the upregulation of IL-6
by activating PAR-2 after systemic exposure to lipopolysaccharide from Porphyromonas
gingivalis. Front Pharmacol 8:470, 2017.
Takayama F, Zhang X, Hayashi Y, Wu Z, Nakanishi H. Dysfunction in diurnal synaptic responses and social behavior abnormalities in cathepsin S-deficient mice. Biochem Biophys Res Commun 490, 447-452, 2017.
Liu Y, Wu Z, Nakanishi Y, Ni J, Hayashi Y, Takayama F, Zhou Y, Kadawaki
T, Nakanishi H. Infection of microglia with Porphyomonas gingivalis promotes
cell migration and an inflammatory response through the gingipain-mediated
activation of protease-activated receptor-2 in mice. Sci Rep Sep 18;7(1):11759, 2017.
総 説
武 洲,中西 博, 歯周病のアルツハイマー病における関与メカニズム：慢性全身性炎症からミクログリア活性化に伴う脳炎症へ, Bio
Clinica 32, 700-705, 2017.
武 洲、中西 博 (2017) 古くて新しいアルツハイマー病の脳炎症仮説と感染症仮説：鍵を握るミクログリアの老化と慢性的脳炎症、日本薬理誌（総説）150,
1-7, 2017.
2016
原著論文
Li X, Wu Z, Ni J, Liu Y, Meng J, Yu W, Nakanishi H, Zhou Y. Cathepsin B regulates collagen expression by fibroblasts via prolonging TLR2/NF-kB activation. Oxid Med Cell Longev 2016:7894247, 2016.
Takayama F, Hayashi Y, Wu Z, Liu Y, Nakanishi H. Diurnal dynamic behavior
of microglia in response to infected bacteria through the UDP-P2Y6 receptor
system. Sci Rep 6: 30006, 2016.
Hayashi Y, Morinaga S, Liu X, Zhang J, Wu Z, Yokoyama T, Nakanishi
An EP2 Agonist Facilitates NMDA-Induced Outward Currents and Inhibits Dendritic
Beading through Activation of BK Channels in Mouse Cortical Neurons
Mediators of Inflammation 2016 (2016), Article ID 5079597, 9 pages
Hayashi Y, Morinaga S, Zhang J, Satoh Y, Meredith A, Nakata T, Wu Z, Kohsaka
S, Inoue K, Nakanishi H.
BK channels in microglia are required for
morphine-induced hyperalgesia.
Nature Commun, 7: 11697, 2016
総 説
林 良憲,中西 博, ミクログリア特異的チャネルの活性化がモルヒネ誘発性痛覚過敏を引き起こす, 実験医学 34,
3032-3035, 2016.
中西 博、総論ミクログリアを標的とした慢性疼痛治療薬への期待、特集
ミクログリアと疼痛 月刊「細胞」ニュー・サイエンス社、48,
2-4, 2016.
林良憲、中西 博、オピオイドのミクログリアを介した副作用とその制御
月刊「細胞」ニュー・サイエンス社、48, 13-16, 2016.
Wu Z, Yu J, Zhu A, Nakanishi H.
Nutrients, microglia aging, and brain aging.
Oxid Med Cell Longev, 2016: 7498528, 2016.
2015
原著論文
Ni J, Wu Z, Peters C, Yamamoto K, Qing
H, Nakanishi H.
The critical role of proteolytic relay through cathepsin B and E on the
phenotipic changes of microglia/macrophage.
J Neurosci, 35, 12488-12501, 2015.
Okada R, Wu Z, Zhu A, Ni J, Zhang J, Yoshimine Y, Peters
C, Saftig P, Nakanishi H
Cathepsin D deficiency induces oxidative damage in brain
pericytes and impairs the blood-brain barrier.
Moll
Cell Neurisci 64, 51-60,
2015.
Zhu A, Wu Z, Meng J, McGeer PL, Zhu Y, Nakanishi H, Wu S.
The neuroprotective effects of Ratanasampil on oxidative
stress-mediated neuronal damage in human neuronal
SH-SY5Y cells.
Oxid Med Cell Longev, 2015: 792342. 2015.
総 説
Wu Z, Nakanishi H
Lessons from microglia aging for the link between
inflammatory bone disorders and Alzheimer's disease.
J
Immun Res, 2015:471342, 2015.
Nakanishi H, Wu Z
Downward spiral of periodontitis and diabetes into
Alzheimer's disease: Extending healthy life expectancy through oral health.
J Oral Biosci, 57, 139-142 2015.
Hayashi Y, Nakanishi H
BK channel in microglia as a potent therapeutic molecular target for
neuropathic pain.
J Oral Biosci, 57, 131-134 2015
随 想
武 洲
ローカルからグローバルへ
J
Soc Japan Women Scientists
15, 48-51, 2015.
2014
原著論文
Hayashi Y, Koga Y, Zhang X, Peters C, Yanagawa Y, Wu Z,
Yokoyama T, Nakanishi H.
Autophagy in superficial spinal dorsal horn accelerates
the cathepsin B-dependent morphine antinociceptive tolerance.
Neuroscience. 2014 Sep 5;275:384-94
Zhang X, Wu Z, Hayashi Y, Okada R, Nakanishi H.
Peripheral Role of Cathepsin S in Th1 Cell-Dependent
Transition of Nerve Injury-Induced Acute Pain to a Chronic Pain State
J Neurosci., 19
February 2014, 34(8):3013-3022
総 説
Nakanishi H
Novel roles of microglia.
Clin
Exp Neuroimmunol (Suppl.
1) 35-40, 2014
Wu Z, Nakanishi H
Connection between periodontitis and Alzheimer's disease:
possible roles of microglia and leptomeningeal cells
J Pharmacol Sci.
2014;126(1):8-13.
Hayashi Y, Wu Z, Nakanishi H
A Possible Link between Microglial Process Dysfunction
and Neuropsychiatric Disorders.
J
Neurol Disord Stroke 2(3):
1060 (2014)
著 書
Bernhardi R, Flores , Nakanishi H
Aging.
Microglia
in Health and Disease
(Eds. Tremblay ME, Sierra A),Springer, pp. 319-341, 2014
2013
総説
林 良憲、中西 博
見えてきたミクログリア突起の動きと働きー注目されるミクログリアのシナプス再編における役割
日薬理誌 142: 231-235, 2013
林 良憲、中西 博
NMDAレセプターとミクログリア：ミクログリアのシナプス可塑性ならびにシナプス再編への関与
特集：NMDAレセプター神経疾患の分子病態を探る
日本神経精神薬理学雑誌 33: 211-216, 2013
Wu Z, Zhi A, Wu S, Nakanishi H
Preventing and reversing "Microglia-Aging" by nature elements for
slow brain-aging
J Neurol Disord,
2013. 2: 143.
原著論文
Liu Y, Wu Z, Zhang X, Ni J, Yu W, Zhou Y, Nakanishi H
Leptomeningeal cells transtuce peripheral macrophages
inflammatory signal to microglia in response to Porphyromonas gingivalis LPS.
Mediators Inflamm,
2013;2013:407562.
Hayashi Y, Koyanagi S, Kusunose N, Okada R, Wu Z,
Tozaki-Saitoh H, Ukai K, Kohsaka S, Inoue K, Ohdo S, Nakanishi H.
The intrinsic microglial molecular clock controls
synaptic strength via the circadian expression of cathepsin S
Scientific Reports
1: 2, 2013
Hayashi Y, Koyanagi S, Kusunose N, Takayama F, Okada R, Wu Z, Ohdo S, Nakanishi
H
Diurnal spatial reorganization of Microglial Processes
through the rhythmic expression of P2Y12 receptors.
Journal of Neurological Disorders.
1:121, 2013 doi: 10.4172/2329-6895.1000120
Wu Z, Zhu A, Takayama F, Okada R, Liu Y, Harada Y, Wu S,
Nakanishi H.
Brazilian green propolis suppresses the hypoxia-induced
neuroinflammatory responses by inhibiting NF-kappaB activation in microglia.
Oxidative Medicine and Cellular
Longevity. 2013; 2013: 906726
Takayama F, Wu Z, Ma HM, Okada R, Hayashi Y, Nakanishi H
Possible involvement of aiPLA2 in the
phosphatidylserine-containing liposomes induced production of PGE2 and PGD2 in
microglia
Journal
of Neuroimmunology.
262: 121-124, 2013
Wu Z, Sun L, Hashioka S, Yu S, Schwab C, Okada R, Hayashi
Y, McGeer PL, Nakanishi H.
Differential pathways for the interleukin-1beta
production activated by chromogranin A and amyloid-beta in microglia.
Neurobiology
of Aging. 34:2715-2725,
2013
著 書
Hayashi Y, Nakanishi H
BK+ Channels Contributes to the Cellular Activation of
Microglia: A big Channel in Small Glia.
In: Glial Cells: Embrionic Development, Types/Functions
and Role in Disease (Eds: Kaur C & Eng Ang L) Nova Science Publisher Inc.,
New York, pp. 167-176, 2013.
Wu Z, Nakanishi H
TNF-alpha Signaling and Cathepsin B, In: Tumor Necrosis
Factor: Structure.
Enzyme Regulation and Role in Health and Disease (Ed:
Escarra A) Nova Science Publisher Inc., New York, pp. 113-128, 2013.
2012
著書
Yamada J, Jinno S, Nakanishi H
Synaptic Stripping and Beyond: Miroglia or Astrocytes?
In: Microglia: Biology, Functions and Roles in Disease
(Eds: Kaur C & Eng Ang L) Nova Science Publisher Inc., New York, pp.
207-217, 2012
原著論文
Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K,
Nakanishi H.
Microglial Cathepsin B Contributes to the Initiation of
Peripheral Inflammation Induced Chronic Pain
J Neurosci, 15
August 2012, 32(33):11330-11342
Liu X, Wu Z, Hayashi Y,
Nakanishi H.
Age-Dependent Neuroinflammatory
Responses and Deficits in Long-Term Potentiation in the Hippocampus During
Systemic Inflammation.
Neuroscience. 2012 Aug 2;216:133-42
2011
原著論文
Hayashi Y, Kawaji K, Sun L, Zhang X, Koyano K, Yokoyama
T, Kohsaka S, Inoue K, Nakanishi H.
Microglial Ca(2+)-activated K(+) channels are possible
molecular target for the analgesic effects of S-ketamine on neruopathic pain.
J Neurosci.
2011 Nov 30;30(48):17370-82.
Nakanishi H, Hayashi Y, Wu Z
The role of microglial mtDNA damage in age-dependent prolonged LPS-induced
sickness behavior.
Neuron Glia Biol.
2011 Oct 28: 1-7.
Yamada J, Nakanishi H, Jinno S.
Differential involvement of perineuronal astrocytes and microglia in
synaptic stripping after hypoglossal axotomy.
Neuroscience. 182, 1-10. 2011
Ma HM, Wu Z, Nakanishi H
Phosphatidylcholine-containing liposomes suppress
inflammatory bone loss by ameliorating the cytokine imbalance in the Ankle
joints of adjuvant arthritic rats.
Lab. Invest.
91, 921-931, 2011
総 説
中西 博
ミクログリアの産生するカテプシンBの機能的多様性 -プロIL-1βのプロセシングと慢性疼痛への関与-
特集 インフラマソーム、生体の科学、62巻 208-212, 2011
Wu Z, Nakanishi H
Phosphatidylserine-containing liposomes: potential
pharmacological interventions against inflammatory and immune diseases through
the production of prostaglandin E2 after uptake by myeloid derived phagocytes.
Ach.
Immunol. Therap. Exp.
59, 195-201, 2011
著 書
Nakanishi H, Wu Z
Cathepsin-dependent neuronal death pathways induced by
methylmercury.
In: Methylmercury: Formation, Sources and Health Effects
(ED., A.P. Clampet) Nova Science Publisher, Inc., New York, 2011, pp81-96
2010
著 書
Wu Z, Nakanishi H
Regulation of myeloid phagocytes by
phosphatidylserine-containing liposomes: possible involvement of prostagrandin
E2 and the potential terapeutic application.In: Prostaglandins: Biochemistry, Functions, Types and Roles (Ed., G.M.
Goodwin) Nova Science Publisher, Inc., New York, pp. 81-92, 2010.
原著論文
Sun L, Wu Z, Baba M, Peters C, Uchiyama Y, Nakanishi H.
Cathepsin B-dependent motor neuron death after nerve
injury in the adult mouse
Biochem
Biophys Res Commun.
2010. Aug 27;399(3):391-5.
Wu Z, Ma HM, Kukita T, Nakanishi Y, Nakanishi H..
Phosphatidylserine-containing liposomes inhibit the
differentiation of osteoclasts and trabecular bone loss.
J Immunol.
2010 Mar 15;184(6):3191-201.
Zhang R, Sun L, Hayashi Y, Liu X, Koyama S, Wu Z,
Nakanishi H.
Acute p38-mediated inhibition of NMDA-induced outward currents in
hippocampal CA1 neurons by interleukin-1beta.
Neurobiol Dis. 2010 Neurobiol Dis.
2010 Apr;38(1):68-77.
Terada K, Yamada J, Hayashi Y, Wu Z, Uchiyama Y, Peters C, Nakanishi H.
Involvement of cathepsin B in the processing and secretion of
interleukin-1beta in chromogranin A-stimulated microglia.
Glia. 2010 Jan 1;58(1):114-24.
2009
総説
Nakanishi H, Wu Z
Microglia-aging: roles of microglial lysosome- and mitochondria-derived
reactive oxygen species in brain aging.
Behav Brain Res. 2009;201(1):1-7
2008
原著論文
Wu Z, Tokuda Y, Zhang XW, Nakanishi H.
Age-dependent responses of glial cells and leptomeninges during systemic
inflammation.
Neurobiol.Dis. 32(3):543-51.
Hayashi Y, Yoshida M, Yamato M, Ide T, Wu Z, Ochi-Shindou
M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi H.
Reverse of age-dependent memory impairment and mitochondrial DNA damage in
microglia by an overexpression of human mitochondrial transcription factor a in
mice.
J.Neurosci.
28(34):8624-34.
Sakamoto M, Miyamoto K, Wu Z, Nakanishi H.
Possible involvement of cathepsin B released by microglia
in methylmercury-induced cerebellar pathological changes in the adult rat.
Neurosci.Lett. 442(3):292-6.
Zhang R, Yamada J, Hayashi Y, Wu Z, Koyama S, Nakanishi
H.
Inhibition of NMDA-induced outward currents by interleukin-1beta in
hippocampal neurons.
Biochem Biophys Res Commun.372(4):816-20.
Yamada J, Hayashi Y, Jinno S, Wu Z, Inoue K, Kohsaka S,
Nakanishi H.
Reduced synaptic activity precedes synaptic stripping in vagal motoneurons
after axotomy.
Glia.56(13):1448-62.
2007
著書
Nakanishi H
Microglia Proteases.
In :Neural Metabolism and Function (Ed., A. Lajtha)
Kluwer Publishing Cooperation, New York, pp.
552-564, 2007.
Wu Z, Nakanishi H
Age-dependent differential activation profiles of glial
cells by the leptomeninges during systemic inflammation.
In: Neuroimmunology Research Focus (Ed., P.V. Broglio)
Nova Science Publisher, Inc., New York, pp. 101-118, 2007.
原著論文
Yamasaki R, Zhang J, Koshiishi I, Sastradipura Suniarti
DF, Wu Z, Peters C, Schwake M, Uchiyama Y, Kira J, Saftig P, Utsumi H,
Nakanishi H
Involvement of lysosomal storage-induced p38 MAP kinase
activation in the overproduction of nitric oxide by microglia in cathepsin
D-deficient mice
Mol
Cell Neurosci.
35(4):573-84.
Hao HP, Doh-Ura K, Nakanishi H.
Impairment of microglial responses to facial nerve axotomy in cathepsin
S-deficient mice.
J Neurosci Res. 85(10):2196-206.
Hashioka S, Han YH, Fujii S, Kato T, Monji A, Utsumi H, Sawada M, Nakanishi H,
Kanba S.
Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit
amyloid beta and interferon-gamma-induced microglial activation.
Free Radic Biol Med.42(7):945-54.
Wu Z, Hayashi Y, Zhang J, Nakanishi H.
Involvement of prostaglandin E2 released from leptomeningeal cells in
increased expression of transforming growth factor-beta in glial cells and
cortical neurons during systemic inflammation.
J Neurosci Res.85(1):184-92
2006
原著論文
Hayashi Y, Tomimatsu Y, Suzuki H, Yamada J, Wu Z, Yao H,
Kagamiishi Y, Tateishi N, Sawada M, Nakanishi H.
The intra-arterial injection of microglia protects hippocampal CA1
neurons against global ischemia-induced functional deficits in rats.
Neuroscience. 2006 Sep
29;142(1):87-96. Epub 2006 Jul 14.
Yamada J, Sawada M, Nakanishi H.
Cell cycle-dependent regulation of kainate-induced inward currents in
microglia.
Biochem Biophys Res Commun.349(3):913-9.
Hayashi Y, Ishibashi H, Hashimoto K, Nakanishi H.
Potentiation of the NMDA receptor-mediated responses through the activation
of the glycine site by microglia secreting soluble factors.
Glia. 2006 Apr 15;53(6):660-8.
Zhang J, Fujii S, Wu Z, Hashioka S, Tanaka Y, Shiratsuchi A, Nakanishi Y,
Nakanishi H
Involvement of COX-1 and up-regulated prostaglandin E synthases in
phosphatidylserine liposome-induced prostaglandin E2 production by microglia.
J Neuroimmunol.172(1-2):112-20.
2005
著書
Nakanishi H
Protease and synaptic activity.
In:
Proteases in the Brain, Proteases in Biology and Disease, Vol. 3 (Eds., U.
Lendeckel and N. Hooper) Springer Science and Business Media Inc., New York,
pp291-310, 2005.
原著論文
Wu Z, Zhang J, Nakanishi H
Leptomeningeal cells activate microglia and astrocytes to induce IL-10
production by releasing pro-inflammatory cytokines during systemic
inflammation.
J Neuroimmunol. 167(1-2):90-8.
Hashioka S, Monji A, Ueda T, Kanba S, Nakanishi H.
Amyloid-beta fibril formation is not necessarily required
for microglial activation by the peptides.
Neurochem Int. 47(5):369-76.
Shimizu T, Hayashi Y, Yamasaki R, Yamada J, Zhang J, Ukai
K, Koike M, Mine K, von Figura K, Peters C, Saftig P, Fukuda T, Uchiyama Y,
Nakanishi H
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of
hippocampal CA3 pyramidal cells in cathepsin D-deficient mice.
J Neurochem.94(3):680-90.
2004
原著論文
Ukai K, Nakagawa T, Ohyama T, Nakanishi H.
Sibutramine induces potential-dependent exocytotic
release but not carrier-mediated release of dopamine and
5-hydroxytryptamine.
Eur J Pharmacol. 484(2-3):209-15,
2004.
2003
総説
Nakanishi H
Neuronal and microglial cathepsins in aging and age-related diseases.
Ageing Res Rev. 2(4):367-81, 2003.
Nakanishi H
Microglial functions and proteases.
Mol Neurobiol. 27(2):163-76, 2003.
原著論文
Moriguchi S, Mizoguchi Y, Tomimatsu Y, Hayashi Y,
Kadowaki T, Kagamiishi Y, Katsube N, Yamamoto K, Inoue K, Watanabe S, Nabekura
J, Nakanishi H
Potentiation of NMDA receptor- mediated
synaptic responses by microglia.
Brain Res Mol Brain Res.
119(2):160-9, 2003.
Okada M, Irie S, Sawada M, Urae R, Urae A, Iwata N, Ozaki
N, Akazawa K, Nakanishi H.
Pepstatin A induces extracellular acidification distinct from aspartic
protease inhibition in microglial cell lines.
Glia 43(2):167-74, 2003.
Koike M, Shibata M, Ohsawa Y, Nakanishi H, Koga T,
Kametaka S, Waguri S, Momoi T, Kominami E, Peters C, Figura Kv, Saftig P,
Uchiyama Y
Involvement of two different cell death pathways in
retinal atrophy of cathepsin D-deficient mice.
Mol Cell Neurosci. 22(2):146-61, 2003.
Zhang J, Miyamoto K, Hashioka S, Hao HP, Murao K, Saido
TC, Nakanishi H
Activation of m-calpain in developing cortical neurons
following methylmercury treatment.
Brain Res Dev Brain Res.
142(1):105-10, 2003.
Okada M, Nakanishi H, Amamoto T, Urae R, Ando S, Yazawa
K, Fujiwara M.
How does prolonged caloric restriction ameliorate
age-related impairment of long-term potentiation in the hippocampus?
Brain Res Mol Brain Res. 111(1-2):175-81, 2003.
2002
総説
Tomimatsu Y, Idemoto S, Moriguchi S, Watanabe S,
Nakanishi H.
Proteases involved in long-term potentiation.
Life Sci. 72(4-5):355-61, 2002.
原著論文
Nishioku T, Hashimoto K, Yamashita K, Liou SY, Kagamiishi
Y, Maegawa H, Katsube N, Peters C, von Figura K, Saftig P, Katunuma N, Yamamoto
K, Nakanishi H
Involvement of cathepsin E in exogenous antigen processing in primary
cultured murine microglia.
J Biol Chem.
277(7):4816-22, 2002.
Moriguchi S, Watanabe S, Kita H, Nakanishi H.
Enhancement of N-methyl- D-aspartate receptor-mediated excitatory
postsynaptic potentials in the neostriatum after methamphetamine sensitization.
An in vitro slice study.
Exp Brain Res. 144(2):238-46, 2002.
2001
原著論文
Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y,
Kominami E, von Figura K, Peters C, Yamamoto K, Saftig P, Uchiyama Y.
Involvement of nitric oxide released from microglia-macrophages in
pathological changes of cathepsin D-deficient mice.
J Neurosci.
21(19):7526-33, 2001.
Baba A, Abe N, Kadowaki T, Nakanishi H, Ohishi M, Asao T,
Yamamoto K.
Arg-gingipain is responsible for the degradation of cell adhesion molecules
of human gingival fibroblasts and their death induced by Porphyromonas
gingivalis.
Biol Chem. 382(5):817-24, 2001.
2000
総説
Tsukuba T, Okamoto K, Yasuda Y, Morikawa W, Nakanishi H,
Yamamoto K.
New functional aspects of cathepsin D and cathepsin
E.
Mol Cells 10(6):601-11, 2000.
原著論文
Nishioku T, Takai N, Miyamoto K, Murao K, Hara C,
Yamamoto K, Nakanishi H.
Involvement of caspase 3-like protease in methylmercury-induced apoptosis of
primary cultured rat cerebral microglia.
Brain Res. 871(1):160-4, 2000.
Noda M, Nakanishi H, Nabekura J, Akaike N.
AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia.
J Neurosci.
20(1):251-8, 2000.
1999
原著論文
Noda M, Nakanishi H, Akaike N.
Glutamate release from microglia via glutamate transporter is enhanced by
amyloid-beta peptide.
Neuroscience 92(4):1465-74, 1999.
Tanabe K, Nakanishi H, Maeda H, Nishioku T, Hashimoto K,
Liou SY, Akamine A, Yamamoto K
A predominant apoptotic death pathway of neuronal PC12 cells induced by
activated microglia is displaced by a non-apoptotic death pathway following
blockage of caspase-3-dependent cascade.
J Biol Chem.
274(22):15725-31, 1999.
Yamamoto Y, Nakanishi H, Takai N, Shimazoe T, Watanabe S,
Kita H
Expression of N-methyl-D-aspartate receptor- dependent long-term
potentiation in the neostriatal neurons in an in vitro slice after ethanol
withdrawal of the rat.
Neuroscience 91(1):59-68, 1999.
Wang HD, Fukuda T, Suzuki T, Hashimoto K, Liou SY, Momoi
T, Kosaka T, Yamamoto K, Nakanishi H.
Differential effects of Bcl-2 overexpression on hippocampal CA1 neurons and
dentate granule cells following hypoxic ischemia in adult mice.
J Neurosci Res. 57(1):1-12, 1999.
Fukuda T, Wang H, Nakanishi H, Yamamoto K, Kosaka T.
Novel non-apoptotic morphological changes in neurons of
the mouse hippocampus following transient hypoxic-ischemia.
Neurosci Res. 33(1):49-55, 1999.
Nishioku T, Shimazoe T, Yamamoto Y, Nakanishi H, Watanabe
S.
Expression of long-term potentiation of the striatum in
methamphetamine- sensitized rats.
Neurosci Lett. 268(2):81-4, 1999.
Amamoto T, Okada M, Kawachi A, Nakanishi H, Yazawa K,
Fujiwara M, Tomonaga M.
Relationship between hippocampal arachidonic acid content and induction of
LTP in aged rats.
Nihon Shinkei Seishin Yakurigaku Zasshi.
19(5):273-7, 1999.
1998
総説
Nakanishi H, Yamamoto K
Involvement of proteinases produced by both
neurons and microglia in neuronal lesion and death pathways.
Nihon Yakurigaku Zasshi 112(2):77-88,
1998.
著書
Nakanishi H, Yamamoto K
Cathepsin E in the central nervous system.
Adv Exp Med Biol. 436:213-7, 1998.
原著論文
Tominaga K, Nakanishi H, Yasuda
Y, Yamamoto
K
Excitotoxin-induced neuronal death is associated with response of a unique
intracellular aspartic proteinase, cathepsin E.
J Neurochem. 71(6):2574-84, 1998.
Takai N, Nakanishi H, Tanabe K, Nishioku T, Sugiyama T,
Fujiwara M, Yamamoto K.
Involvement of caspase-like proteinases in apoptosis of neuronal PC12 cells
and primary cultured microglia induced by 6-hydroxydopamine.
J Neurosci Res. 4(2):214-22, 1998.
Sastradipura DF, Nakanishi H, Tsukuba T, Nishishita K,
Sakai H, Kato Y, Gotow T, Uchiyama Y, Yamamoto K.
Identification of cellular compartments involved in
processing of cathepsin E in primary cultures of rat microglia.
J Neurochem. 70(5):2045 -56, 1998.
Nakanishi H, Miyazaki M, Takai N, Wang HD, Yamamoto T,
Watanabe S, Yamamoto K.
Hyperexcitability of amygdala neurons of senescence-accelerated mouse
revealed by electrical and optical recordings in an in vitro slice preparation.
Brain Res. 812(1-2):142-9, 1998.
1997
原著論文
Nakanishi H, Amano T, Sastradipura DF, Yoshimine Y,
Tsukuba T, Tanabe K, Hirotsu I, Ohono T, Yamamoto K.
Increased expression of cathepsins E and D in neurons of the aged rat brain
and their colocalization with lipofuscin and carboxy-terminal fragments of
Alzheimer amyloid precursor protein.
J Neurochem. 68(2):739-49, 1997.
Nakanishi H, Tamura A, Kawai K, Yamamoto K.
Electrophysiological studies of rat substantia nigra neurons in an in vitro
slice preparation after middle cerebral artery occlusion.
Neuroscience 77(4):1021-8, 1997.
1996
原著論文
Nakanishi H, Kawachi A, Okada M, Fujiwara M, Yamamoto K.
Protective effect of MK-801 on the anoxia-aglycemia
induced damage in the fluorocitrate-treated hippocampal slice of the rat.
Brain Res. 32(1-2):232-6, 1996.
1995
総説
Nakanishi H, Yamamoto K.
Neuronal cell death and intracellular proteinase functions.
Nihon Yakurigaku Zasshi 105(1):1-9,
1995.
著書
Tominaga K, Nakanishi H, Yajima M, Yamamoto K.
Characterization
of cathepsins E and D accumulated at early stages of neuronal damage in
hippocampal neurons of rats.
Adv Exp Med Biol. 362:341-3, 1995.
Nakanishi H, Tominaga K, Yamamoto K.
Increased expression and specific localization of cathepsins E and D in
vulnerable brain regions of aged and postischemic rats.
Adv Exp Med Biol. 362:335-9, 1995.
原著論文
Amano T, Nakanishi H, Oka M, Yamamoto K.
Increased expression of cathepsins E and D in reactive microglial cells
associated with spongiform degeneration in the brain stem of
senescence-accelerated mouse.
Exp Neurol. 136(2):171-82, 1995.
Amano T, Nakanishi H, Kondo T, Tanaka T, Oka M, Yamamoto
K.
Age-related changes in cellular localization and enzymatic activities of
cathepsins B, L and D in the rat trigeminal ganglion neuron.
Mech Ageing Dev. 83(3):133-41, 1995.
Okada M, Nakanishi H, Tamura A, Urae A, Mine K, Yamamoto
K, Fujiwara M.
Long-term spatial cognitive impairment after middle cerebral artery
occlusion in rats: no involvement of the hippocampus.
J Cereb Blood Flow Metab.15(6):1012-21,
1995.
1994
原著論文
Nakanishi H1, Tominaga K, Amano T, Hirotsu I, Inoue T,
Yamamoto K.
Age-related changes in activities and localizations of
cathepsins D, E, B, and L in the rat brain tissues.
Exp Neurol. 126(1):119-28, 1994.
Shindou T, Watanabe S, Kamata O, Yamamoto K, Nakanishi H.
Calcium-dependent hyperexcitability of hippocampal CA1
pyramidal cells in an in vitro slice after ethanol withdrawal of the rat.
Brain Res. 56(2):432-6, 1994.
1993
原著論文
Nakanishi H, Tsukuba T, Kondou T, Tanaka T, Yamamoto K.
Transient forebrain ischemia induces increased expression and specific
localization of cathepsins E and D in rat hippocampus and neostriatum.
Exp Neurol. 121(2):215-23, 1993.
Tsukuba T, Hori H, Azuma T, Takahashi T, Taggart RT,
Akamine A, Ezaki M, Nakanishi H, Sakai H, Yamamoto K.
Isolation and characterization of recombinant human cathepsin E expressed in
Chinese hamster ovary cells.
J Biol Chem.
268(10):7276-82, 1993.
Shindou T, Watanabe S, Yamamoto K, Nakanishi H.
NMDA receptor-dependent formation of long-term potentiation in the rat
medial amygdala neuron in an in vitro slice preparation.
Brain Res Bull. 31(6):667-72, 1993.
1992
原著論文
Nakanishi H1, Yamamoto K, Kita H.
Lateral hypothalamus and local stimulation induced postsynaptic responses in
zona incerta neurons in an in vitro slice preparation of the rat.
Brain Res. 583(1-2):287-91, 1992.
Shindou T, Koizumi S, Kataoka Y, Watanabe S, Yamamoto K,
Nakanishi H.
Inhibitory effect of NMDA on dopaminergic transmission in
a slice preparation of rat globus pallidus.
Jpn J Pharmacol. 58(1):79-82, 1992.
Nakanishi H1, Yamamoto K, Kita H Lateral hypothalamus
and local stimulation induced postsynaptic responses in zona incerta neurons in
an in vitro slice preparation of the rat.
Brain Res. 583(1-2):287-91, 1992.
1991
原著論文
Nakanishi H, Kita H, Kitai ST.
Intracellular study of rat entopeduncular nucleus neurons in an in vitro
slice preparation: response to subthalamic stimulation.
Brain Res. 549(2):285-91, 1991.
Nakanishi H, Kamata O, Ukai K, Yamamoto K.
Inhibitory effects of NMDA receptor antagonists on hypoxia-induced seizures
in dietary Mg2+-deficient mice.
Eur J Pharmacol. 204(1):29-34, 1991.
1990
原著論文
Nakanishi H1, Ukai K, Nakagawa T, Watanabe S, Kamata O,
Yamamoto K.
Enhancement of NMDA receptor-mediated synaptic potential evoked in rat
medial-amygdala neuron following olfactory bulbectomy.
Brain Res. 532(1-2):69-75, 1990.
Nakanishi H, Kita H, Kitai ST.
Intracellular study of rat entopeduncular nucleus neurons in an in vitro
slice preparation: electrical membrane properties.
Brain Res. 527(1):81-8, 1990.
1989
原著論文
Nakanishi H, Kamata O, Katsuda N.
2-amino-5-phosphonovaleric acid blocks induction of an epileptiform
discharge following a brief hypoxic episode in the hippocampal slices prepared
from dietary Mg-deficient mouse.
Jpn J Pharmacol. 50(1):31-6, 1989.
1988
原著論文
Nakanishi H, Kita H, Kitai ST.
An N-methyl-D-aspartate receptor mediated excitatory postsynaptic potential
evoked in subthalamic neurons in an in vitro slice preparation of the
rat.
Neurosci Lett. 95(1-3):130-6, 1988.
1987
原著論文
Nakanishi H, Kita H, Kitai ST.
Intracellular study of rat substantia nigra pars reticulata neurons in an in
vitro slice preparation: electrical membrane properties and response
characteristics to subthalamic stimulation.
Brain Res. 437(1):45-55, 1987.
Nakanishi H, Kita H, Kitai ST..
Electrical membrane properties of rat subthalamic neurons in an in vitro
slice preparation.
Brain Res. 437(1):35-44, 1987.
1985
原著論文
Nakanishi H, Hori N, Kastuda N.
Neostriatal evoked inhibition and effects of dopamine on globus pallidal
neurons in rat slice preparations
Brain Res. 358(1-2):282-6, 1985.
1984
原著論文
Shibata S, Nakanishi H, Watanabe S, Ueki S.
Effects of chronic administration of antidepressants on mouse-killing
behavior (muricide) in olfactory bulbectomized rats.
Pharmacol Biochem Behav.
21(2):225-30, 1984.
Shibata S, Nakanishi H, Ueki S.
Effects of adrenergic blockers on the inhibition of muricide by chronic
administration of desipramine in oflactory bulbectomized rats.
Jpn J Pharmacol. 35(1):73-5, 1984.
1983
原著論文
ffrench-Mullen JM, Hori N, Nakanishi H, Slater NT,
Carpenter DO.
Asymmetric distribution of acetylcholine receptors and M channels on
prepyriform neurons.
Cell Mol Neurobiol. 3(2):163- 81,
1983.
Ueki S, Watanabe S, Yamamoto T, Kataoka Y, Shibata S,
Shibata K, Ohta H, Shimazoe T, Kawamoto H.
Behavioral and electroencephalographic effects of zopiclone, a
cyclopyrrolone derivative.
Fukuoka Igaku Zasshi 74(8):550-67, 1983.
1982
原著論文
Watanabe S, Nakanishi H, Shibata S, Ueki S.
Changes in amygdaloid afterdischarges and kindling effect following
olfactory bulbectomy in the rat.
Physiol Behav. 28(4):687-92, 1982.
1981
原著論文
Shibata S, Watanabe S, Nakanishi H, Ueki S.
Effects of electroconvulsive shock on mouse-killing behavior (muricide) in
olfactory bulbectomized rats.
Jpn J Pharmacol. 31(2):275-80, 1981.
Citations
論文被引用回数ランキング
(Web of Science Core Collection、2016年6月)
218: Koike, M. et al., Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin
in mouse CNS neurons. J Neurosci 20 (18):6898-6906, 2000.
186: Nakanishi, H. et al., Intracellular study of rat substantia nigra pars reticulata neurons in
an in vitro slice preparation: Electrical membrane properties and response
characteristics to subthalamic stimulation. Brain Res 437(1):45-55, 1987.
163: Noda, M. et al., AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J Neurosci 20(1):251-258, 2000.
131: Nakanishi, H. et al., Electrical membrane properties of rat subthalamic neurons in an in vitro
slice preparation. Brain Res 437(1):35-44, 1987.
120: Nakanishi, H. et al., Age-related changes in activities and localizations of cathepsins D, E,
B, and L in the rat brain tissues. Exp Neurol 126(1):119-128, 1994.
108: Noda, M. et al., Glutamate release from microglia via glutamate transporter is enhanced by amyloid-b peptide. Neuroscience 92(4):1465-1474, 1999.
93: Koike, M. et al., Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice. Mol Cell Neurosci 22(2):146-161, 2003.
81: Nakanishi, H. et al., Involvement of nitric oxide released from microglia- macrophages in pathological
changes of cathepsin D-deficient mice. J Neurosci 21(19): 7526-7533, 2001.
81: Nakanishi, H. Neuronal and microglial cathepsins in aging and age-related diseases. Ageing Res Rev 2(4):367-381, 2003.
79: Nakanishi, H. Microglial functions and proteases. Mol Neurobiol 27(2):163-176, 2003.
79: Hayashi. Y. et al., Reverse of age-dependent memory impairment and mitochondrial DNA damage
in microglia by an overexpression of human mitochondrial transcription
factor A in mice. J Neurosi 28(34):8624-8634, 2008.
74: Nakanishi, H., et al. Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein. J Neurochem 68(2):739-749, 1997.
74: Tomimatsu Y. et
al., Proteases involved in long-term potentiation. Life Scie 72(4-5): 355-361, 2002.
72: Sastradipura, D.F. et al., Identification of cellular compartments involved in processing of cathepsin
E in primary cultures of rat microglia. J Neurochem 70(5):2045- 2056, 1998.
69: Nishioku, T. et al., Involvement of cathepsin E in exogenous antigen processing in primary
cultured murine microglia. J Biol Chem 277(7):4816-4822, 2002.
61: Nakanishi, H. et al., Intracellular study of rat entopeduncular nucleus neurons in an in vitro
slice preparation: response to subthalamic stimulation. Brain Res 549(2):285-91, 1991.
58: Nakanishi, H. et al., Transient forebrain ischemia induces increased expression and specific localization of cathepsins E and D in rat hippocampus and neostriatum. Exp Neurol 121(2):215-23, 1993.
57: Tsukuba, T. et al., New functional aspects of cathepsin D and cathepsin E. Mol Cell 10 (6):601-611, 2000.
55: Miyamoto, K-I., et al., Involvement of enhanced sensitivity of N-methyl-D-aspartate receptors
in vulnerability of developing cortical neurons to methylmercury neurotoxicity. Brain Res 90 (1-2):252-258, 2001.
 Impact factor(2016)
インパクトファクターランキング（20164年）
11.470: Nature Communications
1. Hayashi et al., BK channels in microglia are required for morphine-induced hyperalgesia.
Nat Commun 7:11697, 2016.
6.344：Journal of Neuroscience
1. Koike, M. et al., Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin
in mouse CNS neurons. J Neurosci 20(18):6898-6906, 2000.
2. Noda, M. et al., AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. J Neurosci 20 (1): 251-258, 2000.
3. Nakanishi, H., et al., Involvement of nitric oxide released from microglia-macrophages in
pathological changes of cathepsin D-deficient mice. J Neurosci 21(19):7526-7533, 2001.
4. Hayashi, Y. et al., Reverse of age-dependent memory impairment and mitochondrial DNA damage
in microglia by an overexpression of human mitochondrial transcription
factor A in mice. J Neurosci 28(34):8624-8634. 2008.
5. Hayashi, Y. et al., Microglial Ca2+-activated K+ channels are possible
molecular targe for the analgesic effects of S-ketamine on neruopathic pain. J Neurosci 30(48):17370-17382, 2011.
6. Sun, L., Wu, Z. et al. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced
chronic pain. J Neurosci 32(33):11330-11342, 2012.
7. Zhang, Z., Wu, Z., Hayashi. Y. et al., Peripheral role of cathepsin S in Th1 cell- dependent transition of
nerve injury-induced acute pain to a chronic pain state. J Neurosci 34(8):3013-3022, 2014.
8. Ni J., et al. The critical role of proteolytic relay through cathepsins B and E in the phenotypic change of microglia/macrophage. J Neurosci 35(36):1599-1615, 2015.
6.031: Glia
1. Okada, M. et al., Pepstatin a induces extracellular acidification distinct from aspartic
protease inhibition in microglial cell lines. Glia 43(2):167-174, 2003.
2. Hayashi, Y. et al., Potentiation of the NMDA receptor-mediated responses through the
activation of the glycine site by microglia secreting soluble factors. Glia 53(6):660-668, 2006.
3. Yamada, J. et al., Reduced synaptic activity precedes synaptic stripping in vagal motoneurons
after axotomy. Glia 56(13):1448-1462, 2008.
4. Terada, K. et al., Involvement of cathepsin B in the processing and secretion of interleukin-1?
in chromogranin A-stimulated microglia. Glia 8(1):114-124, 2010.
5.736: Free Radical Biology and Medicine
1. Hashioka, S. et al., Phosphatidylserine and phosphatidylcholine-containing liposomes inhibit
amyloid b and interferon-g-induced microglial activation. Free Rad Biol Med 42(7): 945-954, 2007.
5.578: Scientific Reports
1. Hayashi, Y. et al., The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S. Sci Rep 1:2, 2013.
5.137: Molecular Neurobiology
1. Nakanishi, H., Microglial functions and proteases. Mol Neurobiol 27(2):163-176, 2003.
5.078: Neurobiology of Disease
1. Wu, Z. et al., Age-dependent responses of glial cells and leptomeninges during systemic
inflammation. Neurobiol Dis 32(3): 543-551, 2008.
2. Zhang, R. et al., Acute p38-mediated inhibition of NMDA-induced outward currents in hippocampal
CA1 neurons by interleukin-1β. Neurobiol Dis 38(1):68-77, 2010.
5.013: Neurobiology of Aging
1. Wu, Z. et al., Differential pathways for the interleukin-1b production activated by chromogranin
A and amyloid-b in microglia. Neurobiol Aging 34:2715-2725, 2013.
4.940: Ageing Research Reviews
1. Nakanishi, H. Neuronal and microglial cathepsins in aging and age-related diseases.
Ageing Re Rev 2(4)67-381, 2003.
4.922: Journal of Immunology
1. Wu, Z. et al., Phosphatidylserine-containing liposomes inhibit the differentiation of
osteoclasts and trabecular bone loss. J Immunol 184(6):3191-3201, 2010.
4.696: Experimental Neurology
1. Nakanishi, H. et al., Transient forebrain ischemia induces increased expression and specific
localization of cathepsins E and D in rat hippocampus and neonstriatum. Exp Neurol 121(2):215-223, 1993.
2. Nakanishi, H. et al., Age-related changes in activities and localizations of cathepsins D, E,
B, and L in the rat brain tissues. Exp Neurol 126(1):119-128, 1994.
3. Amano, T. et al., Increased expression of cathepsins E and D in reactive microglial cells
associated with spongiform degeneration in the brain stem of senescence-accelerated
mouse. Exp Neurol 136(2):171-182, 1995.
4.573: Journal of Biological Chemistry
1. Tsukuba, T. et al., Isolation and characterization of recombinant human cathepsin E expressed in Chinese hamster ovary cells. J Biol Chem 268(10):7276-7282, 1993.
2. Tanabe, K. et al., A predominant apoptotic death pathway of neuronal PC12 cells induced by
activated microglia is displaced by a non-apoptotic death pathway following
blockage of caspase-3-dependent cascade. J Biol Chem 274 (22):15725-15731, 1999.
3. Nishioku, T. et al., Involvement of cathepsin E in exogenous antigen processing in primary
cultured murine microglia. J Biol Chem 277(7):4816-4822, 2002.
4.281: Journal of Neurochemistry
1. Nakanishi, H. et al., Increased expression of cathepsins E and D in neurons of the aged rat
brain and their colocalization with lipofuscin and carboxy-terminal fragments
of Alzheimer amyloid precursor protein. J Neurochem 68(2):739-749, 1997.
2. Tominaga, K. et al., Excitotoxin-induced neuronal death is associated with response of a unique
intracellular aspartic proteinase, cathepsin E. J Neurochem 71(6):2574-2584, 1998.
3. Shimizu, T. et al., Proteolytic degradation of glutamate decarboxylase mediates disinhibition
of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice. J Neurochem 94 (3):680-690, 2005.
原著論文ベスト10
Nakanishi H, Tominaga K, Amano T, Hirotsu I, Inoue T, Yamamoto K.
Age-related changes in activities and localizations of cathepsins D, E,
B, and L in the rat brain tissues.
Exp Neurol. 126(1):119-28, 1994.
被引用数：116
Nakanishi H, Amano T, Sastradipura DF, Yoshimine Y, Tsukuba T, Tanabe K,
Hirotsu I, Ohono T, Yamamoto K.
Increased expression of cathepsins E and D in neurons of the aged rat brain
and their colocalization with lipofuscin and carboxy-terminal fragments
of Alzheimer amyloid precursor protein.
J Neurochem. 68(2):739-49, 1997.
被引用数：73
Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer
W, Watanabe T, Qaguri S, Kametaka S, Shibata M, Yamamoto K, Kominami E,
Peters C, von Figura K, Uchiyama Y.
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin
in mouse CNS neurons.
J Neurosci 20 (18):6898-6906, 2000.
被引用数：201
Noda M, Nakanishi H, Nabekura J, Akaike N.
AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia.
J Neurosci. 20(1):251-8, 2000.
被引用数：152
Nakanishi H, Zhang J, Koike M, Nishioku T, Okamoto Y, Kominami E, von Figura
K, Peters C, Yamamoto K, Saftig P, Uchiyama Y.
Involvement of nitric oxide released from microglia-macrophages in pathological
changes of cathepsin D-deficient mice.
J Neurosci. 21(19):7526-33, 2001.
被引用数：75
Hayashi Y, Yoshida M, Yamato M,
Ide T, Wu Z, Ochi-Shindou M, Kanki T, Kang D, Sunagawa K, Tsutsui H, Nakanishi
H.?
Reverse of age-dependent memory impairment and mitochondrial DNA damage in microglia by an overexpression of human mitochondrial transcription factor a in mice.
J.Neurosci. 28(34):8624-34, 2008.?
被引用数：61
新聞掲載された研究成果
Wu Z, Ma HM, Kukita T, Nakanishi Y, Nakanishi H.?Phosphatidylserine-containing liposomes inhibit the
differentiation of osteoclasts and trabecular bone loss. J Immunol. 184(6), 3191-201, 2010.
この研究成果は日経産業新聞（2010年6月9日付朝刊）に掲載され、Nature Reviews Rheumatology (6, 245, 2010) のResearch Highlights で紹介された。
Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, Nakanishi
H. Microglial cathepsin B contributes to the initiation of peripheral
inflammation induced chronic pain.
J Neurosci 32(33):11330-11342, 2012.
この研究成果は読売新聞（2012年8月16日付朝刊）、日刊工業新聞（８月１６日付朝刊）ならびに日経産業新聞（8月17日付朝刊）に掲載された。
Zhang X, Wu Z, Hayashi Y, Okada R, Nakanishi H.?Peripheral role of cathepsin S in Th1 cell-dependent transition of nerve
injury-induced acute pain to a chronic pain state.
J Neurosci. 34(8):3013-3022, 2014.
この研究成果は読売新聞（2014年2月20日付夕刊）ならびに西日本新聞（2月21日付朝刊）に掲載され, Pain Research Forum(14/06/20)のEditor's Pick で紹介された。
Ni J, Wu Z, Peters C, Yamamoto K, Qing H, Nakanishi H. The critical role of proteolytic relay through cathepsins B and E in the
phenotypic change of microglia/macrophage. J Neurosci 35(36):1599-1615, 2015.
この研究成果は日刊工業新聞（2015年9月8日付）ならびに科学新聞（10月9日付）に掲載された。
総説ベスト3
Nakanishi H.
Neuronal and microglial cathepsins in aging and age-related diseases.
Ageing Res Rev. 2(4):367-81, 2003.
被引用数：81
Nakanishi H.
Microglial functions and proteases.
Mol Neurobiol. 27(2):163-76, 2003.
被引用数：79
Nakanishi H, Wu Z.
Microglia-aging: roles of microglial lysosome- and mitochondria- derived
reactive oxygen species in brain aging.
Behav Brain Res. 201(1), 1-7,
2009.
被引用数：49
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