| Division |
Section |
Research Subject |
Oral health・
Brain health・
Total health
Research Center |
|
- Anti-metabolic syndrome effect of a bone-derived protein, with a special reference to gender difference.
- Impacts of oral chronic inflammation on brain functions
- Obesity induced plastic changes in functions of taste sensors
- Exploration of oral microbiome associated with human health and disease
- Studies on regeneration of periodontal ligament tissue for long-term maintenance of the teeth
- Development of novel therapeutic approach targeting innate immunity in IgG4-related disease.
- Elucidation of pathogenesis of metabolic syndrome caused by chronic inflammation
- The effect of oral function improvement on the risks of mild cognitive impairment in the elderly people
|
Dento-craniofacial
Development and
Regeneration
Research Center |
|
|
Division of Oral
Biological
Sciences |
Molecular Cell Biology
and Oral Anatomy |
- Molecular mechanism of osteoclast differentiation and activation
- Specific regulation of pathological bone destruction
- Human mesenchymal stem cell-based translational research in regenerative medicine and dental medicine
- Function of mesenchymal stem cells in bone and mineral metabolism
|
Molecular and Cellular
Biochemistry |
- Analysis of the functional interaction among bone, gut and energy metabolism with a special reference to gender difference
- Studies on molecular mechanism of development and its function of salivary gland and teeth
|
Cell Biology,
Aging Science
and
Pharmacology |
- Impacts of chronic systemic inflammation on the brain functions (especially focus on microglia)
- Molecular mechanisms of chronic pain
- Pathophysiological roles of cathepsins in inflammation and pain
- Molecular mechanisms of natural substances controlling inflammation
|
| Oral Neuroscience |
- Understanding of molecular mechanisms of taste signaling associated with various diseases (e.g.taste disorders, metabolic syndromes) and development of therapeutic methods for the diseases
- Taste organ regeneration and functional analysis of taste related molecules by using new 3 dimensional organ culture system (organoid)
- Analysis of taste signaling serving for different functions in multiple organs
- Analysis of regulation of food intake and energy homeostasis via taste signaling in oral-brain-gut axis
|
Oral, Brain and
Total Health Science |
- Please refer to the research content of the Oral health・Brain health・Total health Research Center above for the research content.
|
Division of Oral
Health, Growth
and Development |
Preventive and Public
Health Dentistry |
- Molecular epidemiology on relationship between oral microbiome and oral and systemic health
- Epidemiology on relationship between oral and systemic health
- Clinical study of relationship between oral function and systemic health
- Development of preventive measures of oral diseases utilizing molecular biology
|
Pediatric Dentistry and
Special Need Dentistry |
- Translational research of applying primary tooth to regenerative medicine
- Study of the energy metabolism on craniofacial growth and development
- Molecular analysis of mitochondrial function during dento-craniofacial morphogenesis and development
- Genetic analysis of congenital anomaly of craniofacial complex in children and special need children
|
Orthodontics and
Dentofacial Orthopedics |
- Profiling of microRNAs in embryonic craniofacial development
- Analysis for the molecular mechanisms of tooth development
- Molecular mechanism of the mechanical stress response during chondrogenesis and osteogenesis
- Molecular and developmental biological analysis of the craniofacial region
- Finite element analysis and biomechanics
- An approach to evaluating the physiological and biochemical functions in masticatory muscle fatigue
- Improvement of Quality of Life through orthodontic treatment for patient with malocclusion
|
Division of Oral
Rehabilitation |
Biomaterials |
- Fabrication of carbonate apatite bone replacement
- Development of three-dimensional interconnected bone replacement
- Development of osteoconductivie polymer
- Development of high performance apatite cement
- Analysis of the mechanism of osteoconductivity
|
Endodontology and
Operative Dentistry |
- Studies on identification of factors and scaffolds indispensable for periodontal ligament tissue regeneration
- Studies on the induction of periodontal ligament stem cells derived from iPS cells
- Development of novel pulp capping materials
- Identification of principal molecules in microbes responsible for development of refractory endodontic diseases
- Studies on the pathogenic mechanism and healing process of apical periodontitis
- Studies on the aging of dental pulp cells
|
| Periodontology |
- Studies on the development of new assessment and diagnostic tool for periodontal diseases
- Studies on etiology and bio-regulatory mechanisms of periodontal disease
- Studies on biological periodontal tissue regeneration
- Basic and clinical studies on the interaction between periodontal disease and systemic disease
- Studies on the mechanism of development of low-grade inflammation caused by periodontal disease, and its influence on other tissues
- Studies on the pathogenesis of unique periodontal disease such as drug-induced gingival overgrowth
- Clinical studies on supportive periodontal therapy
|
| Fixed Prosthodontics |
- Studies on esthetic prosthesis
- Studies on tooth regenerative therapy
- Development of inhibitors to alveolar bone resorption
- Analysis of pathogenic mechanisms in peri-implant mucositis and peri-implantitis
- Development of dental implant navigation system using an infrared camera
- Clinical and physiological study on maxillofacial rehabilitation
|
Implant and
Rehabilitative
Dentistry |
- Development of biomaterials for prosthodontic treatment
- Mechanobiology of dental implant and prosthodontics
- Studies on bone regeneration therapy
- Development of evaluation system for stomatognathic function
- Development of evaluation system and treatment of bruxism
- Epidemiological and physiological study on oral rehabilitation using removable dentures
- Epidemiological and biomechanical study on oral rehabilitation using implants
- Establishment of diagnosis and treatment system for temporomandibular disorders
- Development of the treatment for patients with complaints related to occlusion
- Mechanism of chronic masticatory muscle pain
|
Division of
Maxillofacial
Diagnostic and
Surgical Sciences |
Oral Pathology |
- Molecular and genetic investigation on the development and regeneration of the tooth and periodontal tissues for regenerative therapy
- Cellular and molecular biology of oral cancer
- Investigation of a common mechanism of developmental formation and tumor formation
|
Oral and Maxillofacial
Radiology |
- Study on quantitative diagnosis
- Computer-assisted diagnosis using dental images
- Studies on direct digital intraoral imaging system
- Analysis on patient radiation dose in dental radiography
- Diagnostic image analysis for oral cancer
- Image analysis on oral cancers
- Studies on radiotherapy for oral cancers
- Radiological analysis of cervical lymph node metastasis of malignant tumors
- Image analysis on the structure and pathology of salivary glands
- Application of ultrasonography to dentistry
- Image analysis on the structure and pathology of the masticatory muscles and related structures
- Application of “interventional radiology” to dentistry
- Development of the training system for dental radiography using virtual reality technique
|
Oral and Maxillofacial
Surgery |
- Accurate 3 dimensional measurement on cleft lip and palate / jaw deformity
- Development of surgical simulation / navigation system
- A study on bone regeneration and compatible biomaterials
- Development of artificial temporo-mandibular joint
- Development of new treatment method in cleft lip and palate
- Development and evaluation of treatments in jaw deformity
- Molecularly targeted therapy for oral cancer
- A study on the mechanism of invasion and metastasis of oral cancer
- Immunological studies on the pathogenesis of oral mucosal diseases
- Immunological studies on the pathogenesis of Sjögren’s syndrome
- Experimental study on bone regeneration in jaw
|
Oral and Maxillofacial
Oncology |
- Studies on development of the novel treatment for oral cancer
- Clinical studies on reconstructive surgery after the resection of oral cancer
- Studies on host defense mechanism against oral cancer
- Identification of the oncogenes and tumor suppressor genes associated with oral cancer development
- Molecular and genetic investigation on the invasion and metastasis of oral cancer
- Studies on mechanism of the escape from immune surveillance by tumor-associated macrophages of oral cancer
- Studies on the relationship between oral bacterial flora and treatment of oral cancer
- Studies on dysphagia after treatment of oral cancer (evaluation and rehabilitation)
- Immunological studies on pathogenesis of oral mucosal diseases
- Immunological studies on pathogenesis of Sjögren’s syndrome
- Immunological studies on pathogenesis of IgG4-related disease
- Studies on a new therapy tagets for IgG4-related disease and other human autoimmune disease focused on expanded T and B cells -Joint International Research-
- Studies on treatment of odontogenic tumors
- Studies on biological and cytological studies of odontogenic tumors
- Studies on orthognathic surgery for jaw deformities
- Clinical studies on preventive treatment of anti-resorptive agents related osteonecrosis of the jaw
- Studies on pathogenesis and treatment of cleft lip and palate
|
| Dental Anesthesiology |
- Studies on nutrition and metabolism during perioperative period
- Studies on life support for dental emergency
- Studies on clinical pharmacokinetics of aspirin
- Studies on electroencephalogram during general anesthesia
- Studies on depth of tracheal tube during general anesthesia
- Studies on respiratory management during general anesthesia
|
Geriatric Dentistry and
Perioperative Medicine
in Dentistry |
- Studies on the relationship among oral function, systemic disease, and nutrition
- Studies on oral management of patients with systemic disease
- Studies on oral function management for long healthy lives
- Studies on the development of regenerative dental medicine for super-aged society
|
Oral Healthcare and
Dentistry Cooperation |
- Comprehensive studies of dentistry at the time of disaster
- Studies on prevention of deaths associated with disasters
- Studies on meal supports for people vulnerable to disaster
- Studies on dental individual identifying methods with AI
- Studies on food prepared for people having swallowing difficulty with the senses to improve the quality of meal life
- Studies on oral function management and meal supports for patients receiving treatment for cancer
|
Division of
Interdisciplinary
Dentistry |
Interdisciplinary
Dentistry |
- Studies on oral tissue regeneration using stem cell populations and/or stem cell-inducing factors
- Studies on oral care for the perioperative patients
- Studies on the improvement of oral function for ADL elevation of the aged.
- Studies on etiology and bacteria of periodontal disease
- Development of novel training programs and evaluation systems for dental trainees
- Research on mental health status of dental trainees
|
| Dental Education |
- Development of instructional strategies to encourage students to transform themselves into lifelong active learners
- Development of systematic outcome-based educational programs
- Development of ICT-based learning support systems and effective learning materials
- Development of reliable tools to assess students’learning outcomes
- Development of effective faculty development programs
|
Division of Oral
Health,
Technology and
Epidemiology
（Laboratory of
Joint Program） |
Oral Health Promotion
and Technology |
- Diagnostic Technologies for Early Carious Lesions
- Review on Functions of Dentifrice and Toothbrush
- Oral Health and Caries Prevention
- Oral Health and Prevention of Periodontal Diseases/Malodor
- Oral Health and Prevention of Calculus/Staining, Treatment of Dentinal Hypersensitivity
- Development of Screening Systems for Dental Diseases
|
Community Oral Health
and Epidemiology |
- Relationship between Oral Health and Systematic Health
- Relationship between Oral Diseases and Geriatric Diseases
- Role of Oral Health in Super Aged Society
- Development of Oral Health Promotion in Super Aged Society
|
Division of
Advanced Dental
Devices and
Therapeutics
（Donated Fund
Laboratory） |
|
- Studies of bone formation on the bone replacement
- Development of dental adhesion materials with a good effect for soft-tissue healing
- Study of Mesenchymal stem cells behavior around the dental implant
- Studies on soft-tissue regeneration therapy
- Studies of biomaterials for prosthodontic treatment
|